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Acknowledgements This work was supported by National Key R&D Program of China (2024YFF1206400, 2023YFA1801500), National Natural Science Foundation of China (82174033, 32270830, T2350710233), the Nature Science Foundation of Jiangsu Province (BK20230026), Southeast University Interdisciplinary Research Program for Young Scholars (2024FGC1003), Shenzhen Science and Technology Key Program (JCYJ20220818101404009), and Guangdong Provincial Key Laboratory of Multimodality Non-Invasive Brain-Computer Interfaces (2024B1212010010)

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[23] The Werner (WRN) DNA helicase gene, which controls the transcription of the crucial NAD+ biosynthetic enzyme nicotinamide nucleotide adenylyltransferase 1, is the source of WS